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For quite a few chemicals in use every day, there is not enough information to understand all the effects on the environment and human health, but there is now a different way to predict the environmental safety of chemicals by using data from other similar chemicals.

One way to counteract this lack of information is what they did in Europe. That is when the European Union (EU) enacted REACH regulation, which places greater responsibility on industry to manage the risks from chemicals and to provide safety information on the substances.

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The Registration, Evaluation, Authorization and Restriction of Chemical Substances (REACH) regulation came to being in 2006 and requires manufacturers and importers to gather information on the properties of their chemical substances and to register the information in a central database. Regulators said the goal of REACH is to improve the protection of human health and the environment through better and earlier identification of the harmful properties of chemical substances.

In a new research study at Baylor University, researchers said using data from other chemicals, such as what concentrations can cause toxicity in aquatic organisms to predict the toxicity of another chemical that scientists expect causes toxicity in the same way.

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“This study proposes one approach to advance the three R’s of sustainability – reduce, replace, refine – for studying biological impacts of chemicals in the environment,” said study co-author Dr. Bryan Brooks, associate professor of environmental science and biomedical studies and director of environmental health science at Baylor. “Identifying, testing and implementing new approaches to leverage available information to support better environmental decision-making remains a critical need around the world.”

Baylor researchers used statistical and mathematical techniques called chemical toxicity distributions to understand the relative potency of two groups of chemicals.

They then used these findings to develop environmental safety values, which they hope will help determine the environmental impacts of chemical substances without unnecessary testing.

“The biggest hurdle we face when protecting public health and the environment is the general lack of information,” said study co-author Dr. Spencer Williams, a research scientist at Baylor. “The approach we propose should help prioritize the selection of chemicals and organisms for additional safety assessments. Instead of having to test similar chemicals on many organisms over and over again, scientists could estimate safety levels using fewer tests, which could be more efficient without compromising environmental safety.”

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